Oral thrush (white patches in the mouth) that keeps coming back or won't clear up is something that deserves prompt attention, especially with PI. When the immune system isn't functioning properly, fungal infections like this can be harder to control and may even spread. It's really important to contact your immunologist or Show Full Answer
Oral thrush (white patches in the mouth) that keeps coming back or won't clear up is something that deserves prompt attention, especially with PI. When the immune system isn't functioning properly, fungal infections like this can be harder to control and may even spread. It's really important to contact your immunologist or doctor soon — don't wait on this one. A few things they may consider:
- Switching or intensifying antifungal treatment — a daily oral pill like fluconazole may be needed if creams or rinses aren't working
- Reviewing your current PI treatment — your IgG levels or overall immune management may need adjusting
- Checking for a resistant strain — some fungal infections can become resistant to standard treatments
- Considering long-term antifungal therapy — especially if infections keep returning
If the infection spreads beyond the mouth, that's an urgent red flag and needs immediate medical attention. Persistent or worsening oral thrush in people with PI can sometimes be linked to specific PI types that affect how the body fights fungal infections. Your care team is best placed to investigate what's driving this and find the right solution. Don't tough it out — this is exactly what your immunologist is there for.
October 9
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