Common Variable Immunodeficiency (CVID) is one of the most frequently diagnosed types of Primary Immunodeficiency (PI), particularly in adults. It's estimated to affect between 1 in 25,000 and 1 in 50,000 people.
With CVID, the body produces low levels of antibodies — the proteins that help fight off infections. Even Show Full Answer
Common Variable Immunodeficiency (CVID) is one of the most frequently diagnosed types of Primary Immunodeficiency (PI), particularly in adults. It's estimated to affect between 1 in 25,000 and 1 in 50,000 people.
With CVID, the body produces low levels of antibodies — the proteins that help fight off infections. Even though most people with CVID have normal numbers of B cells (the cells that make antibodies), those B cells struggle to mature properly and can't produce enough antibodies to protect the body.
Common symptoms can include:
- Frequent sinus, ear, and respiratory infections
- Digestive issues like chronic diarrhea
- Swollen lymph nodes or an enlarged spleen
- Autoimmune symptoms such as joint pain, low blood counts, or thyroid issues
It's also worth knowing that between 25% and 50% of people with CVID may develop autoimmune complications, where the immune system mistakenly attacks the body's own tissues.
Vaccines may also be less effective for people with CVID, since the immune system doesn't respond to them as strongly as it would in someone without PI.
Because CVID can be caused by different gene mutations, symptoms can vary quite a bit from person to person — so no two experiences are exactly alike!
April 24
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